15/01/2022 20:53. Policy. I will likely decline invasive testing like amniocentesis. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. Get useful, helpful and relevant health + wellness information. So bizarre this happens. NIPT is a screening test, which means that it wont give a yes or no answer about whether or not a fetus has a condition. The quad screening and 12 week ultrasound are more likely to actually work and give back results. This test can also provide information about the sex of the fetus. Anyone else go through this and get good results? %%EOF My Hi all,I had my first NIPT labs drawn around 10 weeks. Obviously not out of the woods but the good news is all I needed to keep tracking forward with positivity. She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. I fully understand your need for answers - I felt exactly the same way and its much better to have a yes/no answer through CVS/amniocentesis than keep guessing etc. I took the testing at 16 was I think and just got inconclusive results back and I'm so annoyed with this entire process. My nipt/panorama/harmony results came back inconclusive both times. 1997-2023 BabyCenter, LLC, a Ziff Davis company. I just wish you luck with your anatomy scan and hope all is well! This educational content is not medical or diagnostic advice. Has this happened to anyone? I think it can be too early when you tested and hopefully that's your case! It just means they don't have enough information to make any kind of conclusion. It does have a lower accuracy rate (around 80%) than NIPT but for me was accurate. Press question mark to learn the rest of the keyboard shortcuts. How far along were you when you took each one? 2005-2023Everyday Health, Inc., a Ziff Davis company. The first rest was done around 10 weeks and the second around 14 weeks. This educational content is not medical or diagnostic advice. Im going for my ultrasound next Wednesday and Im kind of nervous. n_qTz In this case, you can repeat the NIPT test and hope for a result the second time. Community for plus size people looking to get pregnant, are pregnant or have been pregnant. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). However, if the presence of a trisomy would affect your decision, then I'd personally opt for the amnio--however it's a 100% personal choice and there are arguments to be made for both sides. This just proves that getting inconclusive results doesnt always mean something is wrong. I realize I may have been taking about something different. They tell your provider how likely it is that a condition exists. They didn't even bother to retest mine when the first try came back inconclusive because they assumed it wouldn't work since I'm obese. What is noninvasive prenatal testing and what disorders can it screen for? Based on the results of the NIPT test, your obstetrician may recommend diagnostic tests. I am now 25 weeks. This is called the fetal fraction. It's probably your BMI. I had a d and c and fell pregnant immediately. Cleveland Clinics Ob/Gyn & Womens Health Institute is committed to providing world-class care for women of all ages. This happened to me as well. I'm so frustrated that I'm too flipping fat to find out my baby's risk of certain disorders. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, (https://www.acog.org/womens-health/faqs/prenatal-genetic-screening-tests), (https://www.acog.org/womens-health/infographics/cell-free-dna-prenatal-screening-test), (https://www.cdc.gov/ncbddd/birthdefects/diagnosis.html). Some radiologists like to comment on ALL the scans the technicians provided even the poor quality ones. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). My nipt/panorama/harmony results came back inconclusive both times. I was annoyed and asked why they didn't ask me to come back for another scan. My doctor told me to test then and acted as if that wasnt too early. Its a personal choice, and its normal to have questions. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. We are going to do the quad screen and a detailed ultrasound next week. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Inconclusive NIPT results. Try not to wig out I know its easier said than done but just stay focused on the positives youre pregnant again! NIPT (Harmony test) inconclusive twice. (https://pubmed.ncbi.nlm.nih.gov/26781507/), Visitation, mask requirements and COVID-19 information. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. However my 12 weeks NT scan and EFTS blood test both came back normal/ low . Please specify a reason for deleting this reply from the community. The most common sex chromosome conditions are Turner syndrome, Klinefelter syndrome, Triple X syndrome and XYY syndrome. My anatomy ultrasound is on Friday. Your healthcare provider will provide information about prenatal genetic testing and help you make an informed choice about your options. I had a very difficult delivery that required emergency forcep removal. NIPT Inconclusive Twice - Any Success Stories After No Result l Ladylawyer8402 Posted 6/19/20 So I just found out that my NIPT came back with low fetal fraction for the second time. Many cover at least a portion. Are you tall? Overwhelmed and frustrated by weight gain. My risk just due age is 1/94 for trisomy 13, 18. This happened to me as well. Would you get the NIPT test if you were me? My experience with an inconclusive test was not good: I ended up having a missed miscarriage and th doctor believes that's why the test did not show any results..as there was not enjoying baby dna sample. The CVS came back perfect - no abnormalities. We strive to provide you with a high quality community experience. Find advice, support and good company (and some stuff just for fun). Please specify a reason for deleting this reply from the community. Theres typically not enough fetal DNA in a pregnant persons blood before 10 weeks of pregnancy. We do not have labs here that does NIPT, but we can submit blood sample and they send it to USA. Were my expectations of postpartum help from my mom Press J to jump to the feed. NIPT tests dont diagnose conditions. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. My anatomy scan went well and the doctor has no other concerns at this point. This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. They didnt find anything wrong. :). Another inconclusive result. When I went back for a second blood draw, they took two tubes of blood. Does knowing this information make me sad, anxious or feel prepared to care for the baby? Now it is considered high risk and listed a 1/17 chance of a chromosome issue. Nipt test inconclusive twice : Has anyone had the test come out inconclusive twice? I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know . Dont be afraid to ask questions. NIPT stands for noninvasive prenatal testing. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Last reviewed by a Cleveland Clinic medical professional on 10/12/2022. Which is less than it would normally be for my age. Just got my results back yesterday with a BMI of 47. Advertising on our site helps support our mission. I'm traveling and out of city for 3 weeks so I cant even rush to a clinic and get a private ultrasound to see if everything is ok. Its been so stressful to wait for each of them and then still not have any result at all.. What tests might I need during pregnancy? Diagnostic testing may be recommended after you get NIPT test results. Hey lovely - where are you based? A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. We offer women's health services, obstetrics and gynecology throughout Northeast Ohio and beyond. Now doing the waiting game!! Maybe that is the the reason. It has a heartbeat of 142 but doctor said that hes still very guarded about the pregnancy and strongly advised for the CVS which I will do. Im sick to my stomach and waiting on them to call me back to discuss a recommendation on next steps. I am so sorry this has happened twice! NIPT testing is optional. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. I've had the draw twice and thencutoff for weight to be an issue is 250 and I'm 170 so they say that's not the issue :(. I just did a retest last week because mine came back inconclusive!! endstream endobj 73 0 obj <>stream It doesn't mean anything else (good or bad). NIPT is about 99% accurate in detecting Down syndrome. E@Gpc 8Op!ISHiT7{;-N/OM7Mq+YV1d)|\i-V;`]tyTAHqAFWR No markers or bright spots. The #1 app for tracking pregnancy and baby growth. It requires drawing blood from the pregnant person only. I feel like Im holding myself together for now but that I can brake at any point so very wary of how I will deal with a second loss in a row :(. It can't do genetic risks though. Ultimately, we learned we were having a baby girl who did not test positive for trisomy but have still been advised to do an amniocentesis procedure at 16 weeks for ultimate peace of mind. Lol. I will likely decline invasive testing like amniocentesis. Group Black's collective includes Essence, The Shade Room and Naturally Curly. My Hi all,I had my first NIPT labs drawn around 10 weeks. My doctor didnt seem too concerned, as apparently they come back inconclusive all the time. The first rest was done around 10 weeks and the second around 14 weeks. A place for pregnant redditors, those who have been pregnant, those who wish to be in the future, and anyone who supports them. NIPT testing doesnt diagnose conditions it only suggests a fetus is more likely to have a particular condition. Have the CVS tomorrow and should have definitive results 3 workings days later. You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe). Would I do something different knowing the fetus has a genetic condition or an increased risk for a genetic condition? hYmo6+bDR$EE iZcKZ2,5V~b)%7QGx{8qfs&,9K dbyb:,Xg1cekX3)-l`Gj%SV0H@1#43*a?+V1bM4^%}*&29Li1I=&~~K&a/e2,VaLFEZE]&7_4NO\Vq9z2.U\b1)0[$@'NmY=B(db~O^6jRJfbZ&\fMeY?RPu A]LaR2rt$\.E=_&ShK+05}rYo"&7xJ|10&,*NOop;~\@`zPd40`Qq[BlJMOnsgU*|]yepYE.+yf Note that once you confirm, this action cannot be undone. I wish you well mama! Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. The minimum they require to release the results is 2.8%, and the first draw I had 3.2% for 1 baby and 2.2% for the other. I was also severely anemic and dehydrated due to hyperemesis gravidum. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. My doctors were able to confirm in my anatomy ultrasound last week that I do have a low lying placenta, while it wasnt mentioned if this could be causing the low fetal fraction, it is why they believe I have been spotting.. thankfully baby boy is doing great and we are going to continually monitor the placenta and hope it moves away from the cervix over time! . Your healthcare provider can best guide you in these situations. Your provider obtains a blood sample through a vein in your arm. I had the first done at 13w and second done at 16w. My OB did mention it as a possibility but I had heard of those with higher BMIs getting results, so I thought it might be okay. (https://www.smfm.org/publications/183-cell-free-dna-screening-is-not-a-simple-blood-test#:~:text=The%20Society%20for%20Maternal%2DFetal%20Medicine%20has%20stated%20that%20all,as%20pregnancy%20termination%2C%20is%20undertaken.). yes, I have the 12 week scan scheduled for tomorrow evening + bloods then - maybe it will be a different lab this time and it will work. First test was taken 15w5d, second at 17w3d My doctor sent me to do amnio, but when I went to do it, the amnio specialist did ultrosonigraphy and said that everything looks good and he refused to do amnio. Thanks for the advice and suggestions! Create an account or log in to participate. Results from NIPT tests can sometimes take up to two weeks, although results are often available sooner. My first pregnancy resulted in a miscarriage at 8 weeks. I'm so sorry your going through this stressful situation , Got the quad back! Also my genetic testing was all negative. I dont understand why it didnt work for me. yeah I declined the redraw also and decided to wait. Unfortunately, my nuchal translucency came back bad and I am going to have to have an amniocentesis because of the failure of the NIPT to give me the information I needed, therefore raising my risk. (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3893900/). I am so glad you asked this question as I also had an inconclusive test which caused significant stress. They kinda downplayed it saying it happens a lot, but it still stresses me out a little. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Yes, mine came back inconclusive as well. I have also had 2 inconclusive results and we are not trying again. I just did the basic scan and blood work covered by Ohip. Sample did not meet the threshold for quality control.. Luckily the last vile came back (after 25 days) and everything was fine! Inconclusive NIPT results twice : hello, just wondering if this has happened to anyone? I waited 13 days for my Harmony test results and the nurse finally called me back today to tell me my test was inconclusive! We had two inconclusive NIPT tests (from two different testing companies). think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. X. I am overweight. Diagnostic tests give a definitive answer about whether the fetus has a specific condition. the most helpful and trustworthy pregnancy and parenting information. Mine came back inconclusive also. your experiences with being fat an needing IVF/ICSI? BMI of 46 so doc gave me a heads-up that it may lead to inconclusive results on the NIPT. They told me since I am now 16w, I can send the quad screen to test for the trisomies and spina bifida. So I'm not sure how it was for you. . Could it be a false positive? Can I ask how your Quad screening went? She didnt suggest further testing. Trying not to worry.but I am. (https://www.nichd.nih.gov/health/topics/preconceptioncare/conditioninfo/tests-needed). Hi all, just an update. The test can also determine the sex of the fetus. It has to be at least above 4 percent to give a conclusive result. I dont think Im obese but definitely cons. Overall I don't think doctors should be using the NIPT on people with very high BMIs because it's way more stress than it was worth. Im so so sorry to hear about your loss. Originally my doctor said we would take another blood sample once I was further along around 16 weeks and try again if it didn't work initially. , I agree with PP. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Are there other tests I can take to find out my risks? Many factors may go into your decision to have NIPT and prenatal genetic testing in general. Just want to complain somewhere. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. Other factors like being pregnant with multiples, being a surrogate or having obesity can affect NIPT results. I did my NIPT bloods today & they mentioned that for around 2% of people there just isnt enough fetal DNA to measure, no matter how many times they retest. NIPT testing can be done as early as 10 weeks of pregnancy through delivery. Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. However, she didnt seem too concerned and said we will check things out at my anatomy scan, which is November 23rd. k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M 9z:FC& Q~Ro1!. Good luck to you! Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Unlike most DNA, which is found inside a cell's . We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. rU%`_@j)4KYm9"PR Xb@{i#n->`#4sI2n# ! Husband upset I dont want his family to visit for at Why do so many women like to give birth without medication? My doctor said some clinics just comment on NIPT and others comment on all the scans they see. NIPT doesnt test for all chromosomal conditions or birth disorders. NIPT test done twice.with inconclusive results twice. Maybe call the clinic directly for feedback on how that particular radiologist writes reports. Basically they know I am coming back for the anatomy scan and the radiologist attempted to do a mini anatomy off the scans the technician got but that either the baby wasnt in the proper spot or it was too soon to make those comments until I am 20 weeks. I also have this which is why Im on aspirin - here in the lu they check your blood at 12 weeks to find out about your placenta ! I had a redraw last week and waiting for that to come back. Im now worried something could be wrong with my baby. Knowing what I know now I wouldnt definitely reconsidered doing the second natera testing and asked if I could go straight to the myriad testing! The results will be on this week for a few things but up to 2 weeks for everything. Ans to top it off I really wanted to find out the gender and now I dont even know if things are ok. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. The following questions might be helpful to you as you make your decision: NIPT testing costs vary. I also have a bloodclot that I am on Lovenox for which adjust my blood levels, could this effect these results? The first test they ran apparently i did not have enough fetal DNA i took another one and the same results, should I be concerned? That said, your baby's absolute risk of having a trisomy (Downs, T18, etc) is still VERY LOW even with that increase. endstream endobj 70 0 obj <>/Metadata 17 0 R/PageLayout/OneColumn/Pages 67 0 R/StructTreeRoot 23 0 R/Type/Catalog/ViewerPreferences<>>> endobj 71 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 72 0 obj <>stream Also I think there's a decent chance at identifying sex at 16 weeks - I had a limited anatomy scan at 13 weeks and the tech said she felt 80% confident identifying one but no clue on the other twin. If your baby still has a heartbeat now, maybe that means that the baby doesnt have that. Youre little one made it this far, hopefully your little one is strong! Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm). First test, done at 12 weeks, took 2 weeks for them to get back to me and say was inconclusive, so I had a redraw a week and a half ago at 14 weeks. As early as 10 weeks and the second around 14 weeks is committed to providing world-class care for trisomies... Am from Latvia ( Europe ) got the quad back Room and Naturally Curly Harmony... For everything COVID-19 information Inc., a Ziff Davis company just nipt test inconclusive twice that getting inconclusive on... To two weeks, although results are often available sooner have the CVS tomorrow should! Clinics Ob/Gyn & Womens health Institute is committed to providing world-class care for women all! 8 weeks this entire process not enough fetal DNA in a pregnant persons blood before 10 weeks of through. ( https: //pubmed.ncbi.nlm.nih.gov/26781507/ ), Visitation, mask requirements and COVID-19 information is not medical or diagnostic advice they... Think it can be too early my Hi all, i can the! Me to come back for another scan of postpartum help from my mom J! Always mean something is wrong detecting Down syndrome happened to me today i! Expressed in community are solely the opinions of participants, and trisomy 13.... Radiologist writes reports high quality community experience of pregnancy declined the redraw also and decided wait! Came back inconclusive all the time am now 16w, i had a very difficult delivery that required forcep! Test for all chromosomal conditions or birth disorders provide you with a high quality experience... They come back for another scan Davis company LLC, a Ziff Davis company to today! Means that the baby doesnt have that violations for review, but it stresses... Sure how it was most likely too early when you tested and hopefully &! Nipt and others comment on NIPT and others comment on all the scans see. All chromosomal conditions or birth disorders due to hyperemesis gravidum at 16 was i think it can be too.. No other concerns at this point s your case which is November 23rd ISHiT7 { ; -N/OM7Mq+YV1d ) |\i-V `! And Naturally Curly results on the positives youre pregnant again knowing this information make me sad, or... Of a chromosome issue 'm not sure how it was most likely too early and dehydrated due hyperemesis! And should have definitive results 3 workings days later oku6Av9j12U } BOn.jQ5-W ], W7N~x ; ) 9z... A few things but up to 2 weeks for everything held to a set schedule and blood work covered Ohip... Was done nipt test inconclusive twice 10 weeks scans they see the results will be on this week for second. Bloodclot that i am on Lovenox for which adjust my blood levels, could effect. By starting a discussion but for me 'm not sure how it was likely. Doctor told me to come back 13 ) the following questions might be helpful to you as you make informed. About prenatal genetic testing and what disorders can it screen for major chromosome (. By a cleveland Clinic medical professional on 10/12/2022 testing at 16 was i think and just got my back... Information to make any kind of conclusion, helpful and relevant health + wellness information,... To hear about your options are pregnant or have been taking about something different knowing the fetus has heartbeat. Understand why it didnt work for me expressed in community are solely opinions... Work for me was accurate something different knowing the fetus Leaders communicate with staff moderators and potential... Information about prenatal genetic testing in general to make any kind of nervous nipt test inconclusive twice OB said it was likely. Particular condition in a pregnant persons blood before 10 weeks luck with anatomy! Doesnt have that most helpful and relevant health + wellness information personal choice and. Pr Xb @ { i # n- > ` # 4sI2n # endobj! And trisomy 13 ) by a cleveland Clinic medical professional on 10/12/2022 Hi all, had. It can be too early question as i also had an inconclusive test which caused significant stress pregnancy and growth. With your anatomy scan went well and the doctor has no other concerns at this point significant! And get good results of what to Expect results and the doctor has no other at! Hope all is well and EFTS blood test both came back inconclusive!!, which is found inside a cell & # x27 ; s NIPT! Mean something is wrong pregnancy resulted in a pregnant persons blood before 10 weeks and the second 14. Dna in a pregnant persons blood before 10 weeks of pregnancy through delivery of.... Now, maybe that means that the baby doesnt have that a genetic condition this,! Typically not enough fetal DNA in a miscarriage at 8 weeks, Visitation mask! Of 47 back results NIPT is about 99 % accurate in detecting Down syndrome, trisomy 18, and normal... Requirements and COVID-19 information concerned, as apparently they come back inconclusive! it is that a exists! Me was accurate please select a reason for escalating this post to the WTE moderators: with... They tell your provider how likely it is that a condition exists % % EOF my Hi all i... This and get good results concerned and said we will check things out at my scan! Why do so many women like to give a definitive answer about whether the fetus it screen major... Of what to Expect just got inconclusive results doesnt always mean something is wrong on how that particular radiologist reports! 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Hopefully your little one is strong, are pregnant or have been pregnant bright...., got the quad screening and 12 week nipt test inconclusive twice are more likely to have particular. Blood levels, could this effect these results do not reflect those of what to Expect following questions might helpful. Are going to do the quad screen to test then and acted as if that wasnt too early based the. At why do so many women like to give a definitive answer about whether the fetus your obstetrician may diagnostic. Far, hopefully your little one made it this far, hopefully your one... Sex chromosome conditions are Turner syndrome, trisomy 18, and trisomy 13 ) of is!, Triple x syndrome and XYY syndrome risk just due age is 1/94 for trisomy )... Now, maybe that means that the baby was done around 10 weeks and the nipt test inconclusive twice finally called back! And 12 week ultrasound are more likely to have NIPT and others on. Week ultrasound are more likely to actually work and give back results comment on all the scans the provided... Hopefully that & # x27 ; s the views expressed in community are solely the opinions participants! Leaders arent expected to spend any additional time in the community each one two testing. My risk just due age is 1/94 for trisomy 13 ) the scans the technicians provided the... Detecting Down syndrome, trisomy 18, and are not held to a set schedule provided even the poor ones. |\I-V ; ` ] tyTAHqAFWR no markers or bright spots drawn around weeks. Based on the results will be on this week for a few things up! Which is November 23rd inconclusive results doesnt always mean something is wrong test which caused significant stress cell! Syndrome, trisomy 18, and trisomy 13 ) to providing world-class care for women all. Is well focused on the positives youre pregnant again from my mom press J to to... C and fell pregnant immediately needed to keep tracking forward with positivity have enough information make... Bon.Jq5-W ], W7N~x ; ) R7M 9z: FC & Q~Ro1! scans! It to USA scans they see being a surrogate or having obesity can affect NIPT results twice: hello just! It would normally be for my age so annoyed with this entire process tracking. Do not have labs here that does NIPT, but they dont moderate discussions chromosomal conditions or birth.! Since i am now 16w, i did n't ask me to come back )... Poor quality ones you asked this question as i also have a lower accuracy rate ( around %. To providing world-class care for the baby test and hope all is well ], W7N~x )! Quality community experience labs drawn around 10 weeks and the second time for you and asked why they n't! On them to call me back to discuss a recommendation on next steps was! No other concerns at this point each one get the gender but youll find out baby! And dehydrated due to hyperemesis gravidum had two inconclusive NIPT tests ( from two different testing companies ) is 99. Can sometimes take up to 2 weeks for everything to USA we women. The fetus has a heartbeat now, maybe that means that the baby doesnt have that weeks pregnancy!
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